Product Name: Skin Glow Pen
Formulation: 2.6 mL pre-filled pen
Clicks per Pen: 240
Total Amount: 100 mg GHK–Cu
Supplied with: 6 sterile needles (extras available)
Description
GHK–Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring tripeptide-copper complex present in human plasma, saliva, and urine. Its chemical structure is Gly–His-Lys-Cu2+, where the tripeptide backbone (glycine-histidine- lysine) coordinates a Cu(II) ion via the histidine imidazole nitrogen, the lysine ε-amino group, and the N-terminal amine. The copper ion is essential for biological activity
Mechanism of Action
- GHK–Cu exerts broad regenerative, anti-inflammatory, and tissue-remodeling effects through multiple pathways: Copper delivery to enzymes (lysyl oxidase, superoxide dismutase) enhanced collagen/elastin cross-linking and antioxidant defense Modulation of >4,000 genes (upregulation of repair/remodelling genes; downregulation of pro–inflammatory and matrix- degrading genes)
- Stimulation of fibroblast proliferation, glycosaminoglycan and proteoglycan synthesis, and angiogenesis (via VEGF and FGF pathways)
- Suppression of NF-kB and pro-inflammatory cytokines (TNF-a, IL-6)
- Inhibition of MMPs (matrix metalloproteinases) and stimulation of TIMPS (tissue inhibitors of metalloproteinases) Promotion of keratinocyte migration, wound contraction, and extracellular matrix reorganization
- These actions collectively accelerate skin repair, improve barrier function, increase dermal thickness/elasticity, reduce inflammation, and counteract photoaging and chronological skin degeneration.
Indications & Usage
Skin Glow (GHK-Cu) is used to support skin health, repair, and rejuvenation. It is indicated for:
- Promotion of collagen and elastin synthesis, skin firmness, and elasticity
- Acceleration of wound healing and tissue remodelling
- Reduction of inflammation and oxidative damage in skin
- Improvement in skin barrier function, hydration, and overall appearance
- Support for recovery from environmental stress, photoaging, or minor skin trauma
Contraindications & Warnings
Do not use if you have:
- Known hypersensitivity to GHK-Cu, copper, or any excipient
- Active malignancy or history of copper-related disorders (e.g., Wilson’s disease)
- Severe uncontrolled inflammatory skin conditions or open wounds at injection sites
- Pregnancy or breastfeeding
- Age under 18 years
Warnings
- Use only under medical supervision.
- Not a substitute for standard dermatological care, sunscreen use, or approved anti-aging therapies. Avoid injection into inflamed, infected, or broken skin.
- Discontinue immediately and seek medical attention if severe symptoms occur (e.g., widespread rash, swelling, breathing difficulty, or signs of copper toxicity).
Dosage & Administration
- Subcutaneous injection only.
- Standard Dose: 5 mg (12 clicks) once daily
- (1 click≈ 0.417 mg/417 mcg GHK–Cu)
- Alternative/Higher Dose (if tolerated): Up to 10 mg (24 clicks) daily
- Frequency: Once daily
- Timing: Morning, on an empty stomach (wait 30-60 minutes before eating) to optimize absorption
- Cycle: 20 consecutive days on, followed by 2 weeks off (repeat as needed)
Administration Instructions
- Wash hands and prepare a clean surface.
- Attach a sterile needle.
- Dial the required number of clicks (e.g., 12 clicks = 5 mg).
- Clean injection site (abdomen or thigh) with alcohol swab.
- Insert needle at 45-90° angle and inject slowly.
- Withdraw needle, dispose safely, and cap the pen.
- Rotate injection sites to minimize irritation.
- Always inspect solution before use: Do not inject if cloudy, discoloured, or containing particles.
ide Effects
GHK–Cu is generally well tolerated. Reported reactions are uncommon and usually mild/transient, including:
- Mild injection-site irritation, redness, or itching
- Transient headache or light–headedness
- Temporary metallic taste or mild nausea
- Rare skin flushing or changes in energy levels during initial use
- If any severe or persistent symptoms occur (e.g., widespread rash, swelling, breathing difficulty, or signs of copper overload), discontinue use and contact your healthcare provider immediately.
Storage & Handling
- Store either in refrigerator (fridge); never freeze or in a cool dry place (≤25-30°C / 77-86°F).
- Keep pen capped and protected from light and heat.
- After first use: Same storage conditions.
- Keep out of reach of children.
- Discard if expired or solution appears abnormal.
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IMPORTANT NOTICE
This product is not intended to diagnose, treat, cure, or prevent any disease. Statements have not been evaluated by the FDA, SAHPRA, or other authorities. Always consult a licensed healthcare provider before use, especially if pregnant, breastfeeding, under 18, or managing medical conditions.
